Dr. Xiang Zhang: Bone Trauma & Cancer; The Hidden Risk No One Talks About & What to Do

🦴 Bone Metastasis & Cancer: Surprising New Research with Dr. Xiang Zhang

Did you know that bone is one of the most common sites for cancer metastasis? If you've had breast, prostate, lung, renal, liver, or bladder cancer, this is a must-watch conversation.

Dr. Xiang Zhang, a leading cancer researcher at Baylor College of Medicine, joins us to discuss groundbreaking findings on bone metastasis, including:
✔️ How bone fractures, injuries, and even osteoporosis can awaken dormant cancer cells
✔️ Why exercise plays a crucial role in reducing recurrence risk by up to 50%
✔️ How bisphosphonates may help prevent bone metastasis
✔️ New precision therapies being developed to stop bone metastasis in its tracks

As a metastatic breast cancer survivor, this conversation was mind-blowing for me. Understanding these risks is critical for anyone looking to outperform cancer and take control of their health.

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  • 0:00 - Introduction: Why Bone Metastases Matter
    1:16 - Cancer’s Connection to Bone: Key Statistics
    2:09 - The Link Between Bone Trauma & Cancer Recurrence
    3:15 - My Own Story: From Stage 0 to Metastatic
    5:02 - How Bone Fractures Can Wake Up Cancer Cells
    9:22 - Do Osteoporosis & Osteopenia Increase Cancer Risk?
    15:47 - Exercise & Bisphosphonates: How to Reduce Risk
    24:37 - The Immune System’s Role in Bone Metastases
    32:30 - New Precision Therapies: Targeting Bone-Specific Metastases
    48:00 - Future Research & Clinical Trials

    1. Characterization of the immune landscapes of bone metastases from multiple cancer types including breast cancer. 

      https://www.biorxiv.org/content/10.1101/2024.05.07.593027v1

    2. Identification of a role of estrogen receptor in metastasis-associated macrophages using a new cell biology trick that help tagging all host cells coming close to metastatic cells.

      https://www.biorxiv.org/content/10.1101/2024.05.07.593016v1

    3. Elucidation of how breast cancers remotely alter the blood-making process in the bone marrow and impairs the immune system.

      https://pubmed.ncbi.nlm.nih.gov/39266726/

  • For a complete list of clinical trials associated with ascorbate (vitamin C) visit www.clinicaltrials.gov .

    At this time, there are no recruiting studies with bisphosphonates. Use of bisphosphonates has been proven and should be available to all breast cancer patients and perhaps lung cancer patients as the of standard of care.

The Outperform Cancer podcast provides health information and should not be viewed as medical, nursing, or other professional healthcare advice. Listening to or engaging with the content does not create a doctor/patient relationship. Some guests are research scientists and biochemists and not medical doctors. Any reliance on the information from this podcast or linked materials is solely at your own discretion. This podcast's content is not meant to replace professional medical guidance, diagnosis, or care. If you have a medical issue or question, consult with a healthcare professional without delay.

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