Dr. Jed Fahey: Biohacking Cancer, The Promise of Sulforaphane

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In this episode of the @OutperformCancerPodcast, we are honored to have Dr. Jed Fahey, a renowned expert in the field of phytochemicals, as our guest. Dr. Fahey dives deep into the remarkable properties of sulforaphane, a potent phytochemical found abundantly in broccoli sprouts. You'll learn how sulforaphane helps to prevent the onset of cancer, kill active cancer cells, and eliminate the cancer stem cells that chemotherapy can’t kill.

• Chemopreventative Power of Sulforaphane: Discover how this unique phytochemical can help in preventing the onset of cancer.

• Antiproliferative Capabilities: Understand how sulforaphane can slow down or even stop the growth of cancer cells.

• Cancer Stem Cell Elimination: Perhaps one of the most striking features of sulforaphane is its ability to kill cancer stem cells—a feat that even chemotherapy often fails to achieve.

The information Dr. Fahey shares in this video has profound implications for the future of cancer treatment and prevention. As a naturally occurring compound, sulforaphane offers a range of benefits with minimal side effects, making it a subject of intense scientific investigation.

• Timestamp

  00:04:47 What are phytochemicals?

  00:08:10 Broccoli, a phytochemical for cancer prevention

  00:11:10 Not all cruciferous vegetables are the same

  00:12:45 Moringa, the miracle tree, broccoli's twin sister

  00:13:37 Glucoraphanin, the precursor to sulforaphane

  00:18:30 What is a reasonable dose or serving?

  00:22:38 The impact of heat on sulforaphane

  00:25:00 Broccoli sprouts, the benefits and how to grow your own

  00:26:11 Sulforaphane supplements as an alternative to broccoli sprouts 00:36:47 Mechanisms of action for sulforaphane

  00:37:48 Sulforaphane's Nrf2 mediated response and inhibition of cancer tumor initiation, promotion, prevention, metastasis

  00:44:50 Sulforaphane, an indirect antioxidant which is different from an antioxidant

  00:45:50 Length of time sulforaphane is active in the body after ingestion

  00:49:57 Sulforaphane research, mechanisms of effect in breast cancer tissue

  00:56:36 Sulforaphane's impact on cancer stem cells

  01:04:40 Combined effects of sulforaphane and cancer drugs and/or other phytochemicals

  01:06:51 Research (Zhang) on inhibition of angiogenesis and metastasis

  01:09:01 Synergy of sulforaphane and exemestane (aromatase inhibitor)

  01:11:15 Number of peer-reviewed scientific research publications for sulforaphane

  01:14:53 Safety of sulforaphane for cancer patients

  01:16:26 Number of peer-reviewed scientific research publications in past three years

  01:22:12 Wrap-up; summary of highlights, and final thoughts on safety of sulforaphane Description text goes here

• Research Studies Cited

  1. Graham S, Dayal H, Swanson M, Mittelman A, Wilkinson G. Diet in the epidemiology of cancer of the colon and rectum. J Natl Cancer Inst. 1978 Sep;61(3):709-14. PMID: 278848. https://pubmed.ncbi.nlm.nih.gov/278848/

  2. Kuran D, Pogorzelska A, Wiktorska K. Breast Cancer Prevention-Is there a Future for Sulforaphane and Its Analogs? Nutrients. 2020 May 27;12(6):1559. doi: 10.3390/nu12061559. PMID: 32471217; PMCID: PMC7352481. https://pubmed.ncbi.nlm.nih.gov/32471217/

  3. Naujokat C, McKee DL. The "Big Five" Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein. Curr Med Chem. 2021;28(22):4321-4342. doi: 10.2174/0929867327666200228110738. PMID: 32107991. https://www.eurekaselect.com/article/104903

  4. Coutinho LL, Junior TCT, Rangel MC. Sulforaphane: An emergent anti-cancer stem cell agent. Front Oncol. 2023 Jan 23;13:1089115. doi: 10.3389/fonc.2023.1089115. PMID: 36776295; PMCID: PMC9909961. https://pubmed.ncbi.nlm.nih.gov/36776295/

  5. Zhang Y, Tang L. Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta Pharmacol Sin. 2007 Sep;28(9):1343-54. doi: 10.1111/j.1745-7254.2007.00679.x. PMID: 17723168. https://pubmed.ncbi.nlm.nih.gov/17723168/

  6. Hua Liu, Paul Talalay. Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention. PNAS. November 4, 2013 110 (47) 19065-19070. https://doi.org/10.1073/pnas.1318247110 Description text goes here

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